- 中文别名：醋酸奥曲肽
- 中文释义：奥曲肽;tert-butyl (2-aminoethyl)carbamate hydrochloride (1:1);N-Boc-ethylenediamine hydrochloride;[(1S,3aR,4S,6aS)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-dimethoxy-4,1-phenylene)bis-beta-D-glucopyranoside;Eleutheroside D;3-chloro-5-(trifluor
- 英文别名：acetic acid,10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;
Sandostatin;
Sandostatin LAR;
Octreotide acetate (USAN);
Octreotide Acetate;
Octreotide (acetate);
Sandostatin (TN);
zacycloicosane-4-carboxamide acetate - cas No.：79517-01-4
- 分子式：
C49H66N10O10S2
- 分子量：1019.24
- 精确分子量：1018.44000
- PSA：382.82000
- InChI：InChI=1/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,
- 分子结构式：
物化性质
- 外观与性状：
- 无色至灰白色冻干的固体
- 密度：
- 1.395 g/cm3
- 熔点：
- 153-156ºC
- 沸点：
- 1447.228ºC at 760 mmHg
- 闪点：
- 829.053ºC
- 存储条件/存储方法：
- 库房低温,通风,干燥,与食品原料分开存放
- 稳定性相关：
是迄今惟一成功地应用于治疗的胃肠激素类似物，是一个含有环状结构的合成八肽，部分氨基酸序列与生长抑素类似，具备生长抑素的几乎全部生物作用，如抑制多种垂体和胃肠胰激素释放，抑制胃酸、胰液和胆汁分泌，抑制胃肠道运动和分泌等，但半衰期为生长抑素的30倍。
安全信息
- 外观与性状：
- 无色至灰白色冻干的固体
- 密度：
- 1.395 g/cm3
- 熔点：
- 153-156ºC
- 沸点：
- 1447.228ºC at 760 mmHg
- 闪点：
- 829.053ºC
- 存储条件/存储方法：
- 库房低温,通风,干燥,与食品原料分开存放
- 稳定性相关：
是迄今惟一成功地应用于治疗的胃肠激素类似物，是一个含有环状结构的合成八肽，部分氨基酸序列与生长抑素类似，具备生长抑素的几乎全部生物作用，如抑制多种垂体和胃肠胰激素释放，抑制胃酸、胰液和胆汁分泌，抑制胃肠道运动和分泌等，但半衰期为生长抑素的30倍。
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA1000000
- CHEMICAL NAME :
- L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophy l-L-lysyl-L-threonyl- N- (2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic(2-7)-disulfide, (R-(R*,R*))-, acetate (salt)
- CAS REGISTRY NUMBER :
- 79517-01-4
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C49-H66-N10-O10-S2.2C2-H4-O2
- MOLECULAR WEIGHT :
- 1139.49
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2587 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 348,1668,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 1429 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 348,1668,1996
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, allergic (after topical exposure) Skin and Appendages - hair
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5151,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5151,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 72300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,240,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18200 ug/kg/13W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Blood - other changes Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5151,1987